Atropine
Atropine is a naturally occurring belladonna alkaloid that acts as a competitive antagonist of muscarinic acetylcholine receptors. It blocks parasympathetic effects, leading to increased heart rate, decreased secretions, and pupil dilation.
Dosage by Body Weight
Administered intravenously, intramuscularly, subcutaneously, or ophthalmically. Pediatric bradycardia dosing is typically 0.02 mg/kg. Minimum dose is 0.1 mg to prevent paradoxical bradycardia.
- Body Weight
- Below 5 kg
- Dose
- 0.1 mg
- Frequency
- Single dose, may repeat in 3-5 minutes
- Tracking Notes
- Minimum dose of 0.1 mg is recommended to avoid paradoxical slowing of the heart rate.
- Body Weight
- 5-7 kg
- Dose
- 0.1 to 0.14 mg
- Frequency
- Single dose, may repeat in 3-5 minutes
- Tracking Notes
- Based on 0.02 mg/kg dosing. Monitor ECG continuously.
- Body Weight
- 8-10 kg
- Dose
- 0.16 to 0.2 mg
- Frequency
- Single dose, may repeat in 3-5 minutes
- Tracking Notes
- Administer via IV or IO route in emergency bradycardia.
- Body Weight
- 11-15 kg
- Dose
- 0.22 to 0.3 mg
- Frequency
- Single dose, may repeat in 3-5 minutes
- Tracking Notes
- Do not exceed pediatric maximum single dose of 0.5 mg.
- Body Weight
- 16-20 kg
- Dose
- 0.32 to 0.4 mg
- Frequency
- Single dose, may repeat in 3-5 minutes
- Tracking Notes
- Maximum cumulative pediatric dose is 1 mg.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 0.1 mg | Single dose, may repeat in 3-5 minutes | Minimum dose of 0.1 mg is recommended to avoid paradoxical slowing of the heart rate. |
| 5-7 kg | 0.1 to 0.14 mg | Single dose, may repeat in 3-5 minutes | Based on 0.02 mg/kg dosing. Monitor ECG continuously. |
| 8-10 kg | 0.16 to 0.2 mg | Single dose, may repeat in 3-5 minutes | Administer via IV or IO route in emergency bradycardia. |
| 11-15 kg | 0.22 to 0.3 mg | Single dose, may repeat in 3-5 minutes | Do not exceed pediatric maximum single dose of 0.5 mg. |
| 16-20 kg | 0.32 to 0.4 mg | Single dose, may repeat in 3-5 minutes | Maximum cumulative pediatric dose is 1 mg. |
Formulation
Purpose
Used to treat bradycardia (low heart rate), reduce secretions before surgery, act as an antidote for organophosphate poisoning, and dilate pupils during eye examinations.
Generic Name
Atropine SulfateBranded Drug Names
Atropine is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.